Sounds to me like an allergic reaction to the vaccine(s). It would happen just like that....nothing for the 1st set...some reaction for the 2nd set and a much more obvious reaction for the 3rd set. DO NOT VACCINATE this pup again...do titer tests instead. Did the pup get a Lepto vaccine? that is the most common one to cause a reaction...the next reaction could move to throat swelling....don't mess with this one! Keep us posted.

Yes he did get the lepto. Just heard Fort Dodge has had some bad batches along with one other. I feel the vaccine has been the problem all along, just got to find out how to get it cleared up as this pup was on Prednisone for almost 6 weeks way to long and is still not gone completly. I am not real Please with this vet. they are using soon as it happened the first time I knew it had to bee the shots as It did not happen at the 8 week shots.
Thanks everyone! I love this little guy! I even ask to have him back they said NO!