Nemex-2 here. We don't really have much of a problem with worms where we live. I wormed at 4 and 6 weeks and when the pups went to their homes and had their check ups, no one had worms.
I have used Nemex 2 for years at 4, 6, and 8 weeks and they sometimes still have worms. Some of the wormers are becoming resistant to the meds. I just read that somewhere.