Wondering if anyone out there knows a website on a recent study of TVD in labradors. From what I read, it says it is congenital. I have also read were they think if could be genetic? I always thought it was, but am now not sure. If it is genetic, is it a recessive? Let me know!

I haven't seen any recent studies. I always thought of TVD as a birth defect and an isolating thing in most cases unless more than one or two pups in a litter develop it. My vet told me a long time ago when I started with heart clearances that he believed it was not genetic, but just a defect. I have never come up against it myself, so I really haven't looked into it deeply, but this is just what I was told at one point.

Kat

It is my understanding that TVD is a Genetic disease. It can be passed down from only one parent as a recessive. Both parents can be cleared of TVD via a color doppler and still produce a TVD puppy. I could be mistaken but I think it is possible for only 1 parent to pass on the gene to a puppy.

Cleft Palates are considered a congenital condition but there are certain dogs who will consistantly produce Clefts. It makes you wonder if Clefts are not only congenital due to environmental conditions as well as in the dam or sire's genes for puppies to be born with this condition.

If it's recessive, you can't have an affected pup if it comes from only one parent. Recessive means it MUST come from both parents.

The most recent thing I've read says they "know" it's a dominant with incomplete penetrance. To me, that sounds like "we don't know if it's dominant or recessive but this sounds impressive." But then the very mild cases are so hard to see anyways, I'm told.

How I understand TVD. I believe this is the latest theory in TVD research:

http://www.sunsetlabs.com/about_labrador_retrievers/common_inherited_problems.html:

"Research conducted by Dr. Kathy Wright suggests that TVD is caused by a dominant gene with reduced penetrance. Some dogs with the defect gene may not develop TVD, but they can pass the defect gene to their offspring."

http://www.vetsforum.co.uk/article_tricuspid_valve_dysplasia.htm:

"The genetic etiology of TVD in dogs has been recently located to a defective gene on chromosome 9 and is a heritable disorder."

What about siblings of an affected? I know of a big wining bitch with a TVD affected sibling...is there a greater risk of a pppy from that sibling having TVD? Should any siblings of an affected be bred?

Mary Ann, I couldn't get either of those links to work. Do you have any of the articles?

Here are two more links:

http://209.85.165.104/search?q=cache:86VuvCAsnM0J:www.woodhavenlabs.com/documents/TVD-Research-1-03.pdf+Tricuspid+Valve+Dysplasia&hl=en&ct=clnk&cd=6&gl=us&client=firefox-a

http://www.gglrc.org/articles/tvd.shtml

I did speak to Dr. Meg Sleeper recently (from VHUP) and apparently she is looking into doing a TVD study, however funding is an issue.

Is anyone else currently doing research? I understand that the research that Kathy Wright, D.V.M started has not been continued.

Susan

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Replying to:

How I understand TVD. I believe this is the latest theory in TVD research:

http://www.sunsetlabs.com/about_labrador_retrievers/common_inherited_problems.html:

"Research conducted by Dr. Kathy Wright suggests that TVD is caused by a dominant gene with reduced penetrance. Some dogs with the defect gene may not develop TVD, but they can pass the defect gene to their offspring."

http://www.vetsforum.co.uk/article_tricuspid_valve_dysplasia.htm:

"The genetic etiology of TVD in dogs has been recently located to a defective gene on chromosome 9 and is a heritable disorder."

They both opened for me. Here they are though:

Link #1

Link #2

Another Link

Susan, the links do work. You have to remove the : after html.

thanks.....

This might help.

http://209.85.165.104/search?q=cache:zFBXBdw10gUJ:www.geocities.com/
rapeeples/vqa/K9card.html+TVD+breeding+siblings+of+affected+dogs&hl=
en&ct=clnk&cd=2&gl=us&client=firefox-a

"...The incidence in Labradors is not high enough to warrant recommendation to never breed the parents to any other dog or to not breed siblings..."

Though, I'd be careful about the lines of the stud dog to whom you are breeding.

So as not to get flamed by trolls or toads on here, please consult with a board certified veterinary cardiologist for breeding recommendations.

Congenital can be genetic in it's nature.
Meaning: It happens in the womb during development but was predisposed to the condition through genetics...

About 10 years ago a geneticist at University of Penn. was studying TVD. I sent info on one of my dogs. I'm sure you could contact the university for info. It is hereditary. Good luck.

Wondering - Do you have an understanding or genetics and recessive traits?

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Replying to:

Wondering if anyone out there knows a website on a recent study of TVD in labradors. From what I read, it says it is congenital. I have also read were they think if could be genetic? I always thought it was, but am now not sure. If it is genetic, is it a recessive? Let me know!

That doesn't make any sense??? Wondering - do you have an understanding or genetics and recessive traits? Did you mean to say, do you have a understanding of genetics and recessive traits?

Thats what I meant "of" not "or"!