Wendy....the directions (online) for the Panacur 22.2% granules was 1 teaspoon per 25 pounds and dosage for (online) liquid Safe Guard 10% (1 liter) was 1ml per 5 pounds. I did a search for how many teaspoons in a pound (dry matter) and it came out to be 96 teaspoons. If my math is right...the granules can only treat 10 dogs(75 pounds) for three consecutive days (with 6 tsp left over). With the SafeGuard you could treat 10 (75 pounds) using only 450 mls in three days and have enough to treat them again for another three days !! Please correct me if I am wrong ???

Hmmmm...where did you find the number 96? A teaspoon is a measure of volume and a pound is a measure of weight

In any case, there's an easier way to compare. The canine dosage for the granules is 1 mg per 10 pounds of body weight. There are 454 grams in the one pound tub, so it will treat a total of 4540 pounds - or around 1500 pounds of dogs for a three day treatment. It's nearly exactly the same number of doses as the liquid.

Too bad the granules are so much more expensive, because I agree they are easier for the big dogs.