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j
Just Me
Feb 22, 2012 - 12:17PM
Re: Hip Dysplasia study

Or perhaps I could write a thank you letter to Purina for paying PennHIP to prove that feeding has no bearing on eventual arthritic changes (OA). It just delays the inevitable, it would appear. Maybe that is enough to take home from this sort of cross-purpose pseudoscience.

i
Interesting
Feb 22, 2012 - 12:46PM
Re: Hip Dysplasia study

Interesting
Thank you Nancy and Maureen for adding information that makes us think about the article, rather than just simply accept the findings as facts.


I am the FIRST interesting so I would like to thank the ladies for theie comments, doesn't matter that I may not agree with them all. Everything is open to interpretation. Interesting Two, try and be more creative in your alias. LOL

m
more food for thought
Feb 22, 2012 - 9:17PM
Re: Hip Dysplasia study

http://www.vet.cornell.edu/research/bvhip/trends.cfm

j
Just Me
Feb 22, 2012 - 11:28PM
Re: Hip Dysplasia study

Thanks! The report appears to support using phenotype, genetic history (pedigree data) AND laxity scoring (DI or NA) as a combination of criteria for the best outcomes. As I said earlier - complementing instead of competing. It helps to get the view of researchers that don't have a "dog in the fight" - so to speak.

.
.....
Feb 23, 2012 - 5:48AM
Re: Hip Dysplasia study

This is what the report supports...


"The selection index was developed into the Best Linear Unbiased Prediction (BLUP). The BLUP breeding strategy has been used successfully for genetic improvement, particularly in livestock, and has also been applied in closed colonies of dogs with substantial success."

j
Just Me
Feb 23, 2012 - 9:46AM
Re: Hip Dysplasia study

While I am good at statistics, extrapolating a BLUP formula into a working model from a group of hip scores independently is a bit out of my league. I am guessing that is why the authors rolled it into what they call a "breeding value" score for this study.

The portion of the report that I was referencing is from page 5 of the actual study (not the abstract).

Our studies have shown the OFA score and the NA are highly genetically correlated while the DI and the DLS score are also highly genetically correlated but that the genetic correlations between these two groups of hip phenotypes are only moderate [13].
Therefore, selection pressure based on the OFA score will likely not result in as rapid gain as if selection pressure was also exerted
based on either the DI or the DLS score which have higher heritability [23].

In other words, using both types of information may lead to better selection, predictability and outcomes. Cooperation - what a concept!

.
....
Feb 23, 2012 - 9:59AM
Re: Hip Dysplasia study

Only true if you use the entire BLUP formula.

b
Breeder
Feb 23, 2012 - 12:20PM
Re: Hip Dysplasia study

It is not useful to question the motives of the scientists or their sponsors. Just be happy the studies are being done. Plus, keep in mind, whenever someone does a study, the first thing they need to do is to make a statement of what they are hoping to prove. It is NOT like, "Gee, I'll try this on a bunch of dogs and hope something comes up." A lot of studies are done hoping to prove something, only to learn the opposite of what they expected.

.
.....
Feb 24, 2012 - 5:11AM
Re: Hip Dysplasia study

and the researchers/authors of any study report in the research publications the possible limitations of the study and all possible funding conflicts. Are any studies perfect? No, but they can still provide valuable information.

m
Mathlete
Feb 24, 2012 - 10:34AM
Re: Hip Dysplasia study

Here is a primer on how to use BLUP:
http://www4.ncsu.edu/~fisik/course/lecture9_%20blp.pdf
Bon Appetit

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