Is the Cardiac Clear Echo Cardiogram/Color Doppler eough to test a Lab for TVD? I am interested in a puppy whose Granfather had TVD.The Sire of the litter has a Cardiac Clear Echo Cardiogram/Color Doppler.
Thank You
An echo doppler would tell you if the dog had TVD. Unfortunately, with TVD we don't know how it is passed on and/or if it is genetic. You can have two parents that have been tested clear and a pup can have TVD.
The thinking among many experienced breeders and the veterinary community, including cardiologists, is that TVD is autosomal dominant with incomplete penetrance. There may also be modifying and/ or trigger components involved. This means that TVD is not sex-linked and that it only takes one parent to transmit the gene for producing TVD for an offspring to have that gene. At this time, it is impossible to determine whether or not an individual cleared by echo color Doppler is genotypically clear, we can only determine whether or not that individual is phenotypicaly clear, and actually has a physical manifestation of the problem. The best screening tool available at this time is an echo color Doppler. If there is an affected individual within 3 generations, vertically or laterally, you could be at a much more significant risk of producing TVD. The more affected individuals in a pedigree, and the more individuals in a pedigree that have produced TVD, increases the potential of producing TVD. If there is one known affected in a close pedigree, you have no way of knowing whether or not there are many more affected dogs unless EVERY single offspring and relation of that known affected has been echoed.
The thinking among many experienced breeders and the veterinary community, including cardiologists, is that TVD is autosomal dominant with incomplete penetrance. There may also be modifying and/ or trigger components involved. This means that TVD is not sex-linked and that it only takes one parent to transmit the gene for producing TVD for an offspring to have that gene. At this time, it is impossible to determine whether or not an individual cleared by echo color Doppler is genotypically clear, we can only determine whether or not that individual is phenotypicaly clear, and actually has a physical manifestation of the problem. The best screening tool available at this time is an echo color Doppler. If there is an affected individual within 3 generations, vertically or laterally, you could be at a much more significant risk of producing TVD. The more affected individuals in a pedigree, and the more individuals in a pedigree that have produced TVD, increases the potential of producing TVD. If there is one known affected in a close pedigree, you have no way of knowing whether or not there are many more affected dogs unless EVERY single offspring and relation of that known affected has been echoed.
15 years ago, i think this disease was pretty much unheard of in the breed. Now is it just one of the things we have to deal with. So sad.
