Read the fine print. "Should be used with caution in breeding females. Safety has not been established in breeding males." As far as I am concerned, that is enough for me. If you want to know more, I would urge you to contact the makers of the product. I don't have a package with me, but there should be a contact number somewhere on the box or insert.
My sister gave it to her dog at the vets insistance. She called me a couple days later. Dog was really sick and headed back to the vet. It ended up being comfortis. Her dog is ok now.
Seems like my dogs are immune to Advantage and Frontline... Tried Comfortis and it works nicely. However, you have to feed them & then give it to them, otherwise they get sick. If anyone is using anything thing else that works please let me know. Thanks - Leaving my email
