Happened to me also, with Frontline Plus, using Frontline regular, no problems to date.

Same here...I only use the regular Frontline and have had no skin issues. Used to have a male that would react to the Frontline Plus.

You can't always trust when you buy it on line. Many manufactures won't back the product unless its sold by a vet. I always buy it from my vet. May cost a little more but it gives me some piece of mind.

Had the same reaction with Frontline Plus, went back to Regular Frontline

For whatever reason site reactions seem to occur more frequently with Plus than Regular. Also dogs that react to Plus often times will not with Regular. Just what we heard "in the trenches" calling on clinics. Some clinics switched completely back to regular because they were unhappy with the increase in incidence of site reactions. It is a application site reaction to the carrier agent in the product. Hope this helps~!