Thanks everyone who answered here and privately.

So far, all I received was positive feedback.
Laura

Just a follow up.
I had my litter vaccinated with the Nobivac 1-DAPPv vaccine and there were no problems!
Thanks everyone for the very helpful responses.

My repro vet only uses Vanguard and also recommends the product. I never had a problem with the Duramune, but I haven't used it in 4-5yrs. I've been using Vanguard exclusively.